U.S. PHARMACOPEIA

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USP Mafenide Acetate RS—
Determine the water content titrimetrically at the time of use. Keep container tightly closed. Protect from light.

USP Mafenide Related Compound A RS
[4-formylbenzenesulfonamide] (C7H7NO3S 185.20) —Dry portion in vacuum at 60 for 4 hours before using. Keep container tightly closed. Protect from light.

USP Magaldrate RS—
Do not dry before using. Keep container tightly closed, and store in a cool place.

USP Magnesium Salicylate RS—
Dry portion at 105 for 4 hours before using. Keep container tightly closed.

USP Malathion RS—
Do not dry. After opening ampul, transfer contents to a suitable container. Keep container tightly closed and protected from light. Store in a refrigerator.

USP Maleic Acid RS—
Do not dry. Keep container tightly closed and protected from light.

USP Malic Acid RS—
Do not dry before using. Keep container tightly closed and protected from light.

USP Maltitol RS—
Do not dry before using. Keep container tightly closed.

USP Maltol RS.

USP Maltose RS—
Do not dry; determine the water content titrimetrically at the time of use for quantitative analyses. Keep container tightly closed.
Change to read:

USP Maltose Monohydrate RS
—Do not dry. Keep container tightly closed.USP29

USP Mangafodipir Trisodium RS
[manganese(II) dipyridoxal diphosphate]— Do not dry. Hygroscopic. For quantitative applications, determine the water content titrimetrically at the time of use. After opening vial, store tightly closed in a desiccator. Store in a refrigerator.

USP Mangafodipir Related Compound A RS
[manganese(II) dipyridoxal monophosphate sodium salt]— Do not dry. Hygroscopic. After opening vial, store tightly closed in a desiccator. Store in a refrigerator.

USP Mangafodipir Related Compound B RS
[manganese(II) dipyridoxal diphosphate mono overalkylated sodium salt]— Do not dry. Hygroscopic. After opening vial, store tightly closed in a desiccator. Store in a refrigerator.

USP Mangafodipir Related Compound C RS
[manganese(II) dipyridoxal diphosphate sodium salt]— Do not dry. Hygroscopic. After opening vial, store tightly closed in a desiccator. Store in a freezer.

USP Mannitol RS—
Do not dry before using. Keep container tightly closed.

USP Maprotiline Hydrochloride RS—
Dry portion in vacuum at 80 to constant weight before using. Keep container tightly closed.

USP Maritime Pine Extract RS—
Do not dry. Keep container tightly closed and protected from light.

USP Mazindol RS—
Dry portion in vacuum at 60 for 2 hours before using. Keep container tightly closed. Store at a temperature not exceeding 25.

USP Mebendazole RS—
Dry portion at 105 for 4 hours before using. Keep container tightly closed.

USP Mebrofenin RS—
Do not dry. Keep container tightly closed.

USP Mecamylamine Hydrochloride RS—
Dry portion at a pressure not exceeding 5 mm of mercury at 105 for 1 hour before using. Keep container tightly closed. Store in a cool, dry place.

USP Mecamylamine Related Compound A RS
[N,1,7,7-tetramethyl bicyclo [2.2.1] heptan-2-amine] (C11H21N 167.29).

USP Mechlorethamine Hydrochloride RS—
Do not dry before using. This material is hygroscopic. Keep container tightly closed, protected from light.

USP Meclizine Hydrochloride RS—
Do not dry; determine the water content titrimetrically at the time of use. Keep container tightly closed.

USP Meclocycline Sulfosalicylate RS—
Do not dry; determine the water content titrimetrically at the time of use. Keep container tightly closed. Protect from light.

USP Meclofenamate Sodium RS—
Do not dry; determine the water content titrimetrically at time of use. Keep container tightly closed. Protect from light.

USP Medroxyprogesterone Acetate RS—
Do not dry. Keep container tightly closed. Protect from light.

USP Medroxyprogesterone Acetate Related Compound A RS
[4,5-dihydromedroxyprogesterone acetate] (C24H36O4 388.54) —Do not dry before using. Keep container tightly closed.

USP Mefenamic Acid RS—
Do not dry. Keep container tightly closed. Protect from light.

USP Mefloquine Hydrochloride RS.

USP Mefloquine Related Compound A RS
[threo-mefloquine].

USP Megestrol Acetate RS—
Do not dry; determine the water content titrimetrically at time of use. Keep container tightly closed. Protect from light.

USP Melengestrol Acetate RS.

USP Melengestrol Acetate Related Compound A RS
[16-methylene-17-hydroxy-4-pregnene-3,20-dione 17-acetate] —Do not dry. Keep container tightly closed. Protect from light.

USP Melengestrol Acetate Related Compound B RS
[17-hydroxy-6,16-dimethyleneprogna-4-ene-3,20-dione 17-acetate] —Do not dry. Keep container tightly closed. Protect from light.

USP Melphalan Hydrochloride RS—
Do not dry before using. Keep container tightly closed and protected from light. Store in a refrigerator.

USP Menadione RS—
[Caution—Avoid contact; avoid exposure to light. ] Dry portion over silica gel for 4 hours before using. Keep container tightly closed. Protect from light.

USP Menotropins RS.

USP Menthol RS—
Do not dry. This is the L-form of menthol. Keep container tightly closed. Protect from light.

USP Meperidine Hydrochloride RS—
Dry portion in vacuum at a pressure between 20 and 40 mm of mercury at 80 for 4 hours before using. Keep container tightly closed. Protect from light.

USP Mephobarbital RS—
Dry portion at 105 for 4 hours before using. Keep container tightly closed.

USP Mepivacaine Hydrochloride RS—
Dry portion at 105 for 4 hours before using. Keep container tightly closed.

USP Meprednisone RS—
Dry portion at 105 for 3 hours before using. Keep container tightly closed. Protect from light.

USP Meprobamate RS—
Dry portion in vacuum at 60 for 3 hours before using. Keep container tightly closed.

USP Meradimate RS.

USP 3-Mercapto-2-methylpropanoic Acid 1,2-Diphenylethylamine Salt RS
(C4H7O2S·C14H16N 317.45) —Do not dry before using. Keep container tightly closed.

USP Mercaptopurine RS—
Do not dry; determine the water content titrimetrically at time of use. Keep container tightly closed.

USP Meropenem RS—
Do not dry. For quantitative applications, determine the water content titrimetrically at the time of use. Keep container tightly closed. Store in a refrigerator.

USP Mesalamine RS—
Dry portion in vacuum at 105 for 3 hours before using. Keep container tightly closed and protected from light.

USP Mesoridazine Besylate RS—
Do not dry. Keep container tightly closed. Protect from light.

USP Mestranol RS—
Do not dry. Keep container tightly closed. Protect from light.

USP Metaproterenol Sulfate RS—
Dry portion at 105 for 1 hour before using. Keep container tightly closed. Protect from light.

USP Metaraminol Bitartrate RS—
Dry portion at 105 for 2 hours before using. Keep container tightly closed.

USP Metformin Hydrochloride RS—
Do not dry. Keep container tightly closed. Store in a refrigerator. Keep away from alkali.

USP Metformin Related Compound A RS [1-cyanoguanidine]—
Do not dry. Keep container tightly closed. Store in a refrigerator. Keep away from alkali.

USP Methacrylic Acid Copolymer, Type A RS—
Dry portion at 110 for 6 hours before using. Keep container tightly closed.

USP Methacrylic Acid Copolymer, Type B RS—
Dry portion at 110 for 6 hours before using. Keep container tightly closed.

USP Methacrylic Acid Copolymer, Type C RS—
Dry portion at 110 for 6 hours before using. Keep container tightly closed.

USP Methacycline Hydrochloride RS—
Do not dry. Keep container tightly closed. Protect from light. Store in a freezer.

USP Methadone Hydrochloride RS—
Do not dry. Keep container tightly closed. Protect from light.

USP Methamphetamine Hydrochloride RS—
Dry portion at 105 for 2 hours before using. Keep container tightly closed. Protect from light.

USP Methazolamide RS—
Dry portion at 105 for 2 hours before using. Keep container tightly closed. Protect from light.

USP Methdilazine Hydrochloride RS—
Dry portion in vacuum at 65 for 16 hours before using. Keep container tightly closed.

USP Methenamine RS—
Do not dry. Keep container tightly closed.

USP Methenamine Hippurate RS—
Dry portion in vacuum at 60 for 1 hour before using. Keep container tightly closed.

USP Methenamine Mandelate RS—
Dry portion over silica gel for 18 hours before using. Keep container tightly closed.

USP Methicillin Sodium RS—
Do not dry. Determine the water content titrimetrically at the time of use. Keep container tightly closed. Protect from light. Store in a cold place.

USP Methimazole RS—
Dry portion at 105 for 2 hours before using. Keep container tightly closed. Protect from light and store in a freezer.
Change to read:

USP L-Methionine RS—
Do not dry.USP29 Keep container tightly closed.

USP Methocarbamol RS—
Dry portion at 60 for 2 hours before using. Keep container tightly closed.

USP Methohexital RS—
Do not dry. Keep container tightly closed.

USP Methotrexate RS—
This material is hygroscopic. Do not dry; determine the water content titrimetrically at time of use. Keep container tightly closed. Protect from light. Store in a refrigerator.

USP Methotrimeprazine RS—
Dry portion at 100 for 3 hours before using. Keep container tightly closed. Protect from light.

USP Methoxsalen RS—
Do not dry; determine the water content titrimetrically at time of use. Keep container tightly closed. Protect from light.

USP Methoxyflurane RS—
Keep container tightly closed and protected from light.

USP 3-Methoxytyrosine RS—
(NAME CHANGE) See USP Levodopa Related Compound B RS.
Add the following:

USP Methscopolamine Bromide RS—
Dry portion at 105 for 3 hours before using.USP29

USP Methsuximide RS—
Dry portion over phosphorus pentoxide for 16 hours before using. Keep container tightly closed.

USP Methyclothiazide RS—
Dry portion at 105 for 4 hours before using. Keep container tightly closed.

USP Methyclothiazide Related Compound A RS
[4-amino-6-chloro-N3-methyl-m-benzenedisulfonamide] (C7H10ClN3O4S2 299.76) —Dry portion over silica gel for 4 hours before using. Keep container tightly closed and protected from light.

USP Methyl Caprate RS—
Do not dry before using. After opening ampul, store in a tightly closed container, protected from light.

USP Methyl Caproate RS—
Do not dry before using. After opening ampul, store in a tightly closed container, protected from light.

USP Methyl Caprylate RS—
Do not dry before using. After opening ampul, store in a tightly closed container, protected from light. Store in a freezer.

USP Methyl Laurate RS—
Do not dry before using. After opening ampul, store in a tightly closed container, protected from light.

USP Methyl Linoleate RS—
Store in a freezer. Do not dry before using. After opening ampul, discard the unused portion.

USP Methyl Linolenate RS—
Store in a freezer. Do not dry before using. After opening ampul, discard the unused portion.

USP Methyl 5-Methyl-3-isoxazolecarboxylate RS—
Dry portion over silica gel for 4 hours before using. Keep container tightly closed and protected from light.

USP Methyl Myristate RS—
Do not dry before using. After opening ampul, store in a tightly sealed container, protected from light.

USP Methyl Oleate RS—
Store in a freezer. Do not dry before using. After opening ampul, store it in a tightly closed container under an inert gas, protected from light.

USP Methyl Palmitate RS—
Do not dry before using. Keep container tightly closed. Store in a refrigerator.

USP Methyl Palmitoleate RS—
Store in a freezer. Do not dry before using. After opening ampul, store it in a tightly closed container under an inert gas, protected from light.

USP Methyl Stearate RS—
Do not dry before using. Keep container tightly closed. Store in a refrigerator.

USP Methyldopa RS—
Do not dry; determine the water content titrimetrically at time of use. Keep container tightly closed. Protect from light.

USP Methyldopa-Glucose Reaction Product RS.

USP Methyldopate Hydrochloride RS—
Dry portion at a pressure not exceeding 5 mm of mercury at 100 for 2 hours before using. Keep container tightly closed.

USP Methylene Blue RS—
Dry portion at a pressure not exceeding 5 mm of mercury at 75 for 4 hours before using. Keep container tightly closed.

USP Methylergonovine Maleate RS—
Dry portion in vacuum at 80 to constant weight before using. Keep container tightly closed. Protect from light. Store in a refrigerator.

USP 3-O-Methylmethyldopa RS
(C11H15NO4 225.25) —Do not dry. This is the monohydrate form of 3-O-methylmethyldopa. Keep container tightly closed. Protect from light.

USP Methylparaben RS—
Dry portion over silica gel for 5 hours before using. Keep container tightly closed.

USP Methylphenidate Hydrochloride RS—
Dry portion in vacuum at 60 for 4 hours before using. Keep container tightly closed.

USP Methylphenidate Hydrochloride Erythro Isomer Solution RS—
This solution contains 0.5 mL of methylphenidate hydrochloride erythro isomer per mL in methanol. Store in a refrigerator.

USP Methylphenidate Related Compound A RS
[-phenyl-2-piperidineacetic acid hydrochloride] (C13H17NO2·HCl 255.75) —Do not dry before using. Keep container tightly closed.

USP Methylprednisolone RS—
Dry portion at 105 for 3 hours before using. Keep container tightly closed. Protect from light.

USP Methylprednisolone Acetate RS—
Do not dry. Keep container tightly closed. Protect from light. Store in a freezer.

USP Methylprednisolone Hemisuccinate RS—
Do not dry. Keep container tightly closed. Protect from light. Store in a cool place.

USP Methyltestosterone RS—
Dry portion at 105 for 4 hours before using. Keep container tightly closed. Protect from light.

USP Methysergide Maleate RS—
Dry portion in vacuum at 120 for 2 hours before using. Keep container tightly closed. Protect from light.

USP Metoclopramide Hydrochloride RS—
Do not dry; determine the water content titrimetrically at time of use for quantitative analyses. Keep container tightly closed. Protect from light.

USP Metolazone RS—
Dry portion at 105 for 2 hours before using. Keep container tightly closed. Protect from light.

USP Metoprolol Fumarate RS—
Dry portion in vacuum at 60 for 4 hours before using. Keep container tightly closed and protected from light.

USP Metoprolol Related Compound A RS
[(±)1-ethylamino)-3-[4-(2-methoxyethyl)phenoxy]-propan-2-ol] (C14H23NO3 253.34) —Do not dry. Keep container tightly closed. Protect from light. Store in a freezer.

USP Metoprolol Related Compound B RS
[(±)1-chloro-2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]-propane] (C12H17ClO3 244.71) —Do not dry. Keep container tightly closed. Protect from light. Store in a freezer.

USP Metoprolol Related Compound C RS
[(±)4-[2-hydroxy-3-(1-methylethyl)aminopropoxy]benzaldehyde] (C13H19NO3 237.29) —Do not dry. Keep container tightly closed. Protect from light. Store in a freezer.

USP Metoprolol Related Compound D RS
[(±) N,N-bis[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl](1-methylethyl)amine] (C27H41NO6 475.62) —Do not dry. Keep container tightly closed. Protect from light. Store in a freezer.

USP Metoprolol Succinate RS—
Do not dry. Keep container tightly closed. Protect from light.

USP Metoprolol Tartrate RS—
Keep container tightly closed. Protect from light.

USP Metrifonate RS [trichlorfon]—
Do not dry. Keep container tightly closed, protected from light, and store in a refrigerator.

USP Metronidazole RS—
Dry portion at 105 for 2 hours before using. Keep container tightly closed. Protect from light.

USP Metronidazole Benzoate RS—
Dry at 80 for 3 hours.

USP Metyrapone RS—
Dry portion in vacuum at room temperature for 6 hours before using. Keep container tightly closed. Protect from light. Store in a cool, dry place.

USP Metyrosine RS—
Dry portion at a pressure not exceeding 5 mm of mercury at 100 for 2 hours before using. Keep container tightly closed.

USP Mexiletine Hydrochloride RS—
Dry portion at 105 for 2 hours before using. Keep container tightly closed.

USP Mezlocillin Sodium RS—
Do not dry. For quantitative applications, determine the water content titrimetrically at the time of use. Keep container tightly closed, and store in a cool, dry place. This material is hygroscopic.

USP Mibolerone RS.

USP Miconazole RS—
Dry portion in vacuum at 60 for 4 hours before using. Keep container tightly closed. Protect from light.

USP Miconazole Nitrate RS—
Dry portion at 105 for 2 hours before using. Keep container tightly closed. Protect from light.

USP Powdered Milk Thistle Extract RS—
Dry portion at 105 for 2 hours before using.

USP Milrinone RS—
Do not dry. For quantitative applications, determine the water content titrimetrically at the time of use. This material is hygroscopic. Keep container tightly closed.

USP Milrinone Related Compound A RS
[1,6-dihydro-2-methyl-6-oxo-(3,4¢-bipyridine)-5-carboxamide] (C12H11N3O2 229.23) —Do not dry. This material is hygroscopic. Keep container tightly closed.

USP Minocycline Hydrochloride RS—
Do not dry before using. Keep container tightly closed. Protect from light. Store in a cold place.

USP Minoxidil RS—
Do not dry before using. Keep container tightly closed.

USP Mirtazapine RS
—Do not dry; determine the water content titrimetrically at the time of use. Keep container tightly closed. Protect from light.

USP Mitomycin RS—
Do not dry before using. Keep container tightly closed. Protect from light. Store in a cold dry place.

USP Mitotane RS—
Dry portion in vacuum at 60 for 2 hours before using. Keep container tightly closed. Protect from light.

USP Mitoxantrone Hydrochloride RS—
Do not dry; determine the water content titrimetrically at the time of use. Keep container tightly closed. This material is hygroscopic.

USP Mitoxantrone System Suitability Mixture RS
[9, 10-anthracenedione, 8-amino-1,4-dihydroxy-5[[2-[(2-hydroxyethyl)amino]ethyl]amino]-, hydrochloride] (C18H19N3O5·HCl 393.83) —Do not dry. Keep container tightly closed.

USP Molindone Hydrochloride RS—
Dry portion at 105 to constant weight before using. Keep container tightly closed. Protect from light.

USP Mometasone Furoate RS—
Dry portion at 105 for 3 hours before using. Keep container tightly closed.

USP Monensin Sodium RS.

USP Monobenzone RS—
Dry portion at 105 for 3 hours before using. Keep container tightly closed. Protect from light. Avoid exposure to temperatures above 30.

USP Monoglycerides RS—
Do not dry before using. Keep container tightly closed and protected from light.

USP Monostearyl Maleate RS—
Do not dry. Keep container tightly closed.

USP Morantel Tartrate RS—
Do not dry. Keep container tightly closed. Protect from light. After opening, store in a desiccator.

USP Moricizine Hydrochloride RS—
Do not dry. For quantitative applications, determine the water content titrimetrically. Keep container tightly closed.

USP Morphine Sulfate RS—
This is the pentahydrate form. Do not dry before using, except as instructed for compliance with official standards. Determine the water content titrimetrically at time of use. Keep container tightly closed. Protect from light.

USP Mupirocin RS—
Do not dry before using. Keep container tightly closed, and store in a freezer.

USP Mupirocin Lithium RS—
Do not dry before using. Keep container tightly closed, and store in a freezer.