U.S. PHARMACOPEIA

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Sodium Phosphates Oral Solution
» Sodium Phosphates Oral Solution is a solution of Dibasic Sodium Phosphate and Monobasic Sodium Phosphate, or Dibasic Sodium Phosphate and Phosphoric Acid, in Purified Water. It contains, in each 100 mL, not less than 16.2 g and not more than 19.8 g of dibasic sodium phosphate (Na2HPO4·7H2O), and not less than 43.2 g and not more than 52.8 g of monobasic sodium phosphate (NaH2PO4·H2O).
Packaging and storage— Preserve in tight containers.
Identification— It responds to the tests for Sodium 191 and for Phosphate 191.
Specific gravity 841: between 1.333 and 1.366.
pH 791: between 4.4 and 5.2.
Residual solvents 467: meets the requirements.
(Official January 1, 2007)
Assay— Pipet 25.0 mL of Oral Solution into a 500-mL volumetric flask, dilute with water to volume, and mix. Transfer 25.0 mL of this stock solution to a 250-mL beaker, and add 15.0 mL of 0.5 N sodium hydroxide and 75 mL of water. Proceed as directed in the Assay under Sodium Phosphates Rectal Solution, beginning with “Titrate the excess base.”
Auxiliary Information— Staff Liaison : Elena Gonikberg, Ph.D., Scientist
Expert Committee : (MDGRE05) Monograph Development-Gastrointestinal Renal and Endocrine
USP29–NF24 Page 1989
Phone Number : 1-301-816-8251