NF Monographs: Sodium Propionate

Sodium Propionate

C3H5NaO2·xH2O

Propanoic acid, sodium salt, hydrate.
Sodium propionate hydrate

[6700-17-0].

Anhydrous 96.06

[137-40-6].

» Sodium Propionate, dried at 105

for 2 hours, contains not less than 99.0 percent and not more than 100.5 percent of C3H5NaO2.

Packaging and storage— Preserve in tight containers.

USP Reference standards

— USP Sodium Propionate RS.

Identification—

A: Infrared Absorption

197K

, on undried specimen.

B: A solution (1 in 20) responds to the tests for Sodium

191

Alkalinity— Dissolve 2.0 g in 20 mL of water, and add phenolphthalein TS: if a pink color is produced, it is discharged by 0.60 mL of 0.10 N sulfuric acid.

Water, Method I

921

: not more than 1.0%.

Heavy metals, Method I

231

— Dissolve 2 g in 1 mL of 1 N acetic acid and sufficient water to make 25 mL: the limit is 0.001%.

Organic volatile impurities, Method I

467

: meets the requirements.

Residual solvents

467

: meets the requirements.

(Official January 1, 2007)

Assay— Dissolve about 200 mg of Sodium Propionate, previously dried at 105

for 2 hours and accurately weighed, in 50 mL of glacial acetic acid. Add 1 drop of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 9.606 mg of C3H5NaO2.

Auxiliary Information— Staff Liaison : Catherine Sheehan, B.Sc., Scientist

Expert Committee : (EM105) Excipient Monographs 1

USP29–NF24 Page 3426

Phone Number : 1-301-816-8262


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